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Zarasyl Science

Equine Dermatology Conditions

Equine skin conditions are a frequent and often frustrating part of caring for horses.

Until now, the challenge has been finding a reliable, effective product to predictably manage the skin conditions being diagnosed in horses.

Thankfully, you now have ONE product to solve the most common skin conditions that affect horses.

Zarasyl Equine

The Novel, High Tech Solution For Dermatological Problems in Horses

“An ideal wound healing modality should provide a moist environment, offer protection from secondary infections, eliminate wound exudate, and stimulate tissue regeneration”
‍
[Hussain 2017].
Over a decade of scientific research has been conducted to perfect the patented, novel technology contained in Zarasyl Equine Barrier Cream. Zarasyl is steroid and antibiotic free.

Zarasyl’s formula creates a superior moisturizing environment for wound care, which is known to be ideal for wound healing.

Zarasyl contains a proprietary amorphous silica with a molecular structure tailored to provide sustained delivery of orthosilicic acid to the skin. Orthosilicic acid is the bioavailable form of silicon associated with healthy connective tissue growth.

Silica (SiO2) is the oxide of silicon, the most abundant essential trace element in animals after iron and zinc. It occurs in crystalline form, such as quartz, or amorphous form, such as bottle glass and the silica found in plants. Amorphous silica is non-toxic via oral, dermal and ocular routes of exposure. In water it dissolves to form orthosilicic acid (Si(OH)4), the bioavailable form of silicon that's associated with healthy connective tissue growth.

Zarasyl contains PEG 400 as a topical disinfecting agent that works by drawing water from bacterial cells. Additionally, PEG 400 has been shown to exhibit specific antibacterial activity against gram-negative bacteria. PEG 400 is effective for management of inflammatory skin disease, scar tissue formation and enhancing the repair of damaged skin, mucosa or wounds.

All ingredients are odorless, non-volatile, water miscible, chemically stable, nonirritating and non-toxic.Zarasyl is oil free and being water based ensures a moist, semi-occlusive environment.

Ingredients

Contains Polyethylene Glycol 3350, Polyethylene Glycol 400, Propylene Glycol, Water, Phenoxyethanol, Polysilicic acid, Sodium Chloride.

Instructions For Use

Clean and dry the affected area before use. Apply Zarasyl liberally once or twice daily to all your horse’s scratches, cuts, sores, wounds and infections. Apply bandaging or a dressing when indicated

Precautions

For external use only. For equine animal use only. Store in cool dry conditions. Do not combine Zarasyl with other creams or ointments. Keep out of reach of children.

‍Studies for Reference

  1. Carlisle EM. “Silicon.” In: O’Dell BL, Sunde RA, editors. Handbook of Nutritionally Essential Mineral Elements. New York, NY: Marcel Dekker; 1997:603–618.
  2. Reffitt DM, et al. “Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.” Bone 32 (2003) 127-35.
  3. Hanasano M, et al. “The effect of silicone gel on basic fibroblast growth factorlevels in fibroblast cell culture.” Arch Facial Plast Surg 6 (2004) 88-93.
  4. Jugdaohsingh R. “Silicon and bone health.” J Nutr Health Aging 11 (2007) 99-110.
  5. Jugdaohsingh R, et al. “Increased longitudinal growth in rats on a silicon-depleteddiet.” Bone 43 (2008) 596-606.
  6. Porter AE, et al. “Ultrastructural comparison of dissolution and apatite precipitationon hydroxyapatite and silicon-substituted hydroxyapatite in vitro and invivo.” J Biomed Mater Res A 69 (2004) 670-679.
  7. Herreros, FO, et al. “Remodeling of the human dermis after application of salicylatesilanol.” Arch Dermatol Res 299 (2007) 41-45.
  8. Miñones J, et al. “The interaction of silicic acid with protein monolayers: effect of pHand ionic strength of substrate.” J Colloid Interface Sci 42 (1973) 503–515.
  9. Quignard S, et al. “Silica nanoparticles as sources of silicic acid favoring woundhealing in vitro.” Colloid Surf B 155 (2017) 530-537.
  10. Vis B, et al. “Non-functionalized ultrasmall silica nanoparticles directly andsize-selectively activate T cells.” ACS Nano 12 (2018) 10843-10854.
  11. Vis B, et al. “Ultrasmall silica nanoparticles directly ligate the T cell receptorcomplex.” Proc Natl Acad Sci (2019) in revision.
  12. Havran W, Jameson J “Epidermal T cells and wound healing.” J Immunol 184(2010) 5423–5428.
  13. Chirife J, et al. “In vitro antibacterial activity of concentrated polyethylene glycol400 solutions.” Antimicrob Agents Chemotherapy 24 (1983) 409-412.
  14. Van den Plas D, et al. “Use of polyethylene glycol in inflammation related topicaldisorders or diseases and wound healing” EP 1 988 909 B1 (2008).
  15. Zahid Hussain, et al. “Hyaluronic Acid-Based Biomaterials: A Versatile and Smart Approach to Tissue Regeneration andTreating Traumatic, Surgical, and Chronic Wounds” Polymer Reviews (2017) 57:4,594-630.